| EpCAM in carcinogenesis: the good, the bad or the ugly BTF van der Gun, LJ Melchers, MHJ Ruiters, LFMH de Leij, ... Carcinogenesis 31 (11), 1913-1921, 2010 | 408 | 2010 |
| Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders S Ligthart, A Vaez, U Võsa, MG Stathopoulou, PS De Vries, BP Prins, ... The American Journal of Human Genetics 103 (5), 691-706, 2018 | 393 | 2018 |
| Genetic evidence of assortative mating in humans MR Robinson, A Kleinman, M Graff, AAE Vinkhuyzen, D Couper, ... Nature Human Behaviour 1 (1), 0016, 2017 | 338 | 2017 |
| Epigenetic reprogramming of cancer cells via targeted DNA methylation AG Rivenbark, S Stolzenburg, AS Beltran, X Yuan, MG Rots, BD Strahl, ... Epigenetics 7 (4), 350-360, 2012 | 337 | 2012 |
| The timeline of epigenetic drug discovery: from reality to dreams A Ganesan, PB Arimondo, MG Rots, C Jeronimo, M Berdasco Clinical epigenetics 11, 1-17, 2019 | 321 | 2019 |
| Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver CL Van Der Wilt, JR Kroep, WJP Loves, MG Rots, CJ Van Groeningen, ... European Journal of Cancer 39 (5), 691-697, 2003 | 310 | 2003 |
| Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner D Cano-Rodriguez, RAF Gjaltema, LJ Jilderda, P Jellema, ... Nature communications 7 (1), 12284, 2016 | 297 | 2016 |
| Epigenetic Editing : targeted rewriting of epigenetic marks to modulate expression of selected target genes ML de Groote, PJ Verschure, MG Rots Nucleic acids research 40 (21), 10596-10613, 2012 | 222 | 2012 |
| Differential effects of NF-κB and p38 MAPK inhibitors and combinations thereof on TNF-α-and IL-1β-induced proinflammatory status of endothelial cells in vitro JM Kułdo, J Westra, SA Asgeirsdóttir, RJ Kok, K Oosterhuis, MG Rots, ... American Journal of Physiology-Cell Physiology 289 (5), C1229-C1239, 2005 | 208 | 2005 |
| Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation activity AN Siddique, S Nunna, A Rajavelu, Y Zhang, RZ Jurkowska, R Reinhardt, ... Journal of molecular biology 425 (3), 479-491, 2013 | 199 | 2013 |
| Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome CM Zwaan, GJL Kaspers, R Pieters, K Hählen, GE Janka-Schaub, ... Blood, The Journal of the American Society of Hematology 99 (1), 245-251, 2002 | 199 | 2002 |
| Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer S Stolzenburg, MG Rots, AS Beltran, AG Rivenbark, X Yuan, H Qian, ... Nucleic acids research 40 (14), 6725-6740, 2012 | 192 | 2012 |
| Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter H Chen, HG Kazemier, ML de Groote, MHJ Ruiters, GL Xu, MG Rots Nucleic acids research 42 (3), 1563-1574, 2014 | 191 | 2014 |
| Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia MG Rots, R Pieters, GJ Peters, P Noordhuis, CH Van Zantwijk, ... Blood, The Journal of the American Society of Hematology 93 (5), 1677-1683, 1999 | 180 | 1999 |
| A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo K Ogawara, MG Rots, RJ Kok, HE Moorlag, AM Van Loenen, DKF Meijer, ... Human gene therapy 15 (5), 433-443, 2004 | 177 | 2004 |
| Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice FJ Bustos, E Ampuero, N Jury, R Aguilar, F Falahi, J Toledo, J Ahumada, ... Brain 140 (12), 3252-3268, 2017 | 164 | 2017 |
| The influence of eukaryotic chromatin state on CRISPR–Cas9 editing efficiencies SAN Verkuijl, MG Rots Current opinion in biotechnology 55, 68-73, 2019 | 133 | 2019 |
| Therapeutic modulation of endogenous gene function by agents with designed DNA‐sequence specificities TG Uil, HJ Haisma, MG Rots Nucleic acids research 31 (21), 6064-6078, 2003 | 123 | 2003 |
| Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase MGP van der Wijst, M Venkiteswaran, H Chen, GL Xu, T Plösch, MG Rots Epigenetics 10 (8), 671-676, 2015 | 113 | 2015 |
| Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression MGP van der Wijst, AY van Tilburg, MHJ Ruiters, MG Rots Scientific reports 7 (1), 177, 2017 | 110 | 2017 |
