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Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy CX Dominguez, S Müller, S Keerthivasan, H Koeppen, J Hung, S Gierke, ... Cancer discovery 10 (2), 232-253, 2020 | 620 | 2020 |
USP7 small-molecule inhibitors interfere with ubiquitin binding L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ... Nature 550 (7677), 534-538, 2017 | 307 | 2017 |
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance R Drost, P Bouwman, S Rottenberg, U Boon, E Schut, S Klarenbeek, ... Cancer cell 20 (6), 797-809, 2011 | 300 | 2011 |
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events J Liu, W Lee, Z Jiang, Z Chen, S Jhunjhunwala, PM Haverty, F Gnad, ... Genome research 22 (12), 2315-2327, 2012 | 241 | 2012 |
A resource for cell line authentication, annotation and quality control M Yu, SK Selvaraj, MMY Liang-Chu, S Aghajani, M Busse, J Yuan, G Lee, ... Nature 520 (7547), 307-311, 2015 | 226 | 2015 |
Recurrent loss of NFE2L2 exon 2 is a mechanism for Nrf2 pathway activation in human cancers LD Goldstein, J Lee, F Gnad, C Klijn, A Schaub, J Reeder, A Daemen, ... Cell reports 16 (10), 2605-2617, 2016 | 195 | 2016 |
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types MC Wagle, D Kirouac, C Klijn, B Liu, S Mahajan, M Junttila, J Moffat, ... NPJ precision oncology 2 (1), 7, 2018 | 155 | 2018 |
A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants P Bouwman, H van der Gulden, I van der Heijden, R Drost, CN Klijn, ... Cancer discovery 3 (10), 1142-1155, 2013 | 151 | 2013 |
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 R Drost, KK Dhillon, H Van Der Gulden, I Van Der Heijden, I Brandsma, ... The Journal of clinical investigation 126 (8), 2903-2918, 2016 | 134 | 2016 |
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer J Liu, M McCleland, EW Stawiski, F Gnad, O Mayba, PM Haverty, ... Nature communications 5 (1), 3830, 2014 | 105 | 2014 |
Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients HM Horlings, C Lai, DSA Nuyten, H Halfwerk, P Kristel, E van Beers, ... Clinical Cancer Research 16 (2), 651-663, 2010 | 97 | 2010 |
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma SM Kas, JR De Ruiter, K Schipper, S Annunziato, E Schut, S Klarenbeek, ... Nature genetics 49 (8), 1219-1230, 2017 | 92 | 2017 |
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma I Yen, F Shanahan, J Lee, YS Hong, SJ Shin, AR Moore, J Sudhamsu, ... Nature 594 (7863), 418-423, 2021 | 90 | 2021 |
Pharmacological induction of RAS-GTP confers RAF inhibitor sensitivity in KRAS mutant tumors I Yen, F Shanahan, M Merchant, C Orr, T Hunsaker, M Durk, H La, ... Cancer Cell 34 (4), 611-625. e7, 2018 | 87 | 2018 |
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors TJ Hagenbeek, JD Webster, NM Kljavin, MT Chang, T Pham, HJ Lee, ... Science signaling 11 (547), eaaj1757, 2018 | 83 | 2018 |
A preclinical mouse model of invasive lobular breast cancer metastasis CW Doornebal, S Klarenbeek, TM Braumuller, CN Klijn, M Ciampricotti, ... Cancer research 73 (1), 353-363, 2013 | 81 | 2013 |
Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data C Klijn, H Holstege, J de Ridder, X Liu, M Reinders, J Jonkers, L Wessels Nucleic acids research 36 (2), e13-e13, 2008 | 80 | 2008 |
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer C Bowman-Colin, B Xia, S Bunting, C Klijn, R Drost, P Bouwman, ... Proceedings of the National Academy of Sciences 110 (21), 8632-8637, 2013 | 73 | 2013 |
High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors MJ Koudijs, C Klijn, L van der Weyden, J Kool, J ten Hoeve, D Sie, ... Genome Research 21 (12), 2181-2189, 2011 | 53 | 2011 |