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Hunter Nisonoff
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Learning protein fitness models from evolutionary and assay-labeled data
C Hsu, H Nisonoff, C Fannjiang, J Listgarten
Nature biotechnology 40 (7), 1114-1122, 2022
1472022
XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment
Y Lee, D Bogdanoff, Y Wang, GC Hartoularos, JM Woo, CT Mowery, ...
Science advances 7 (17), eabg4755, 2021
982021
Algorithms for protein design
P Gainza, HM Nisonoff, BR Donald
Current opinion in structural biology 39, 16-26, 2016
772016
OSPREY 3.0: Open‐source protein redesign for you, with powerful new features
MA Hallen, JW Martin, A Ojewole, JD Jou, AU Lowegard, MS Frenkel, ...
Journal of computational chemistry 39 (30), 2494-2507, 2018
722018
A deep-learning view of chemical space designed to facilitate drug discovery
P Maragakis, H Nisonoff, B Cole, DE Shaw
Journal of Chemical Information and Modeling 60 (10), 4487-4496, 2020
402020
Epistatic Net allows the sparse spectral regularization of deep neural networks for inferring fitness functions
A Aghazadeh, H Nisonoff, O Ocal, DH Brookes, Y Huang, OO Koyluoglu, ...
Nature communications 12 (1), 5225, 2021
382021
Combining evolutionary and assay-labelled data for protein fitness prediction
C Hsu, H Nisonoff, C Fannjiang, J Listgarten
bioRxiv, 2021.03. 28.437402, 2021
322021
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
AM Taylor, BR Williams, F Giordanetto, EH Kelley, A Lescarbeau, ...
Journal of Medicinal Chemistry 66 (19), 13384-13399, 2023
172023
Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes
PH Yoon, P Skopintsev, H Shi, LX Chen, BA Adler, M Al-Shimary, ...
Nucleic Acids Research 51 (22), 12414-12427, 2023
122023
Discovery and validation of the binding poses of allosteric fragment hits to protein tyrosine phosphatase 1b: From molecular dynamics simulations to X-ray crystallography
JB Greisman, L Willmore, CY Yeh, F Giordanetto, S Shahamadtar, ...
Journal of Chemical Information and Modeling 63 (9), 2644-2650, 2023
112023
Efficient Partition Function Estimatation in Computational Protein Design: Probabalistic Guarantees and Characterization of a Novel Algorithm
H Nisonoff
Duke University Durham, 2015
62015
Augmenting neural networks with priors on function values
H Nisonoff, Y Wang, J Listgarten
arXiv preprint arXiv:2202.04798, 2022
52022
Sparse epistatic regularization of deep neural networks for inferring fitness functions
A Aghazadeh, H Nisonoff, O Ocal, Y Huang, OO Koyluoglu, J Listgarten, ...
bioRxiv, 2020.11. 24.396994, 2020
52020
RNA language models predict mutations that improve RNA function
Y Shulgina, MI Trinidad, CJ Langeberg, H Nisonoff, S Chithrananda, ...
bioRxiv, 2024
32024
Coherent Blending of Biophysics-Based Knowledge with Bayesian Neural Networks for Robust Protein Property Prediction
H Nisonoff, Y Wang, J Listgarten
ACS Synthetic Biology 12 (11), 3242-3251, 2023
32023
Molecular Graph Generation from Structural Features Using an Artificial Neural Network
P Maragakis, H Nisonoff, P Skopp, J Salmon
US Patent App. 17/614,856, 2022
32022
Unlocking Guidance for Discrete State-Space Diffusion and Flow Models
H Nisonoff, J Xiong, S Allenspach, J Listgarten
arXiv preprint arXiv:2406.01572, 2024
22024
Mapping the biochemical landscape of rubisco
N Prywes, NR Phillips, LM Oltrogge, B de Pins, AE Cowan, ...
22023
Discovery and validation of the binding poses of allosteric fragment hits to PTP1B: From molecular dynamics simulations to X-ray crystallography
JB Greisman, L Willmore, CY Yeh, F Giordanetto, S Shahamadtar, ...
bioRxiv, 2022.11. 14.516467, 2022
22022
GENTANGLE: integrated computational design of gene entanglements
JM Martí, C Hsu, C Rochereau, C Xu, T Blazejewski, H Nisonoff, ...
Bioinformatics 40 (7), 2024
2024
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